THE MYF SHIFT

NIH's Forward Funding Revolution

Traditional Model

Annual installments
Shutdown vulnerable
Carryover needs approval

MYF Model

5-year upfront payment
Shutdown proof
Full spending flexibility

Active Grant Reduction

Shifting to 50% forward funding could decrease total active grants from 10,000 to 6,200

10,000
Traditional grants
6,200
MYF grants (-38%)

⚠️ Critical Impact on ESIs

Early Stage Investigators without bridge funding may struggle to survive 4-year gaps between funding cycles, disproportionately affecting new researchers.

Funding Cash Flow Comparison

How money flows over a 5-year project period

Incremental Funding

20% of budget released each year. Creates "out-year mortgages" that tie up future budgets.

Forward Funding (MYF)

100% of 5-year budget paid upfront in Year 1. Eliminates future obligations, enables rapid pivots.

New Discussion Tier System

Applications divided into thirds based on committee voting

33%

Discussed

Top third - full study section review

33%

Competitive ND

Still eligible for funding

33%

Not Competitive

Not discussed, not funded

💡 The "Competitive ND" Strategy

If your grant falls in the middle tier, contact your Program Officer to explain how you'll use the lump sum to front-load high-impact equipment or data collection in Year 1.

Note: NIH no longer permits paylines - each funding decision must be individually justified.

The Year-by-Year Impact

DrugMonkey's "spherical cow" analysis: Assuming 400 total R01s with 100 expiring annually

FY2025
40
vs 100 potential
FY2026
72
vs 180 potential
FY2027
98
vs 245 potential
FY2028
118
vs 296 potential

Payline Collapse

4th

Percentile at NCI (end of FY2025) - down from ~7th percentile

Success Rate Plunge

~10%

Expected success rate, down from ~20% in recent years

Data sources: Former NIGMS Director Jeremy Berg analysis, DrugMonkey analysis, NIH policy documents